杜杰，首都医科大学，首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所 教授 博士生导师

杜杰教授1985年北京大学生物系学士，1989年中国农科院取得博士学位，当年赴美国留学。先后作为博士后，讲师，助理教授，副教授在美国Emory University School of Medicine, Baylor College of Medicine 从事心血管，高血压发生及其危害，肿瘤方面的研究。曾主持及参与多项美国NIH R01 心血管研究课题。2008年任教育部长江特聘教授。2008年获得国家自然科学基金杰出青年称号。 2010年教育部心血管重塑相关疾病重点实验室主任，2011年教育部长江创新主动脉瘤研究团队主任。目前任北京安贞医院院长助理，北京市心肺血管研究所副所长，教授， 主持包括 国家“973”课题，北京市心血管病理生理平台课题，国家自然科学基金重大、重点等基金。累计发表100篇SCI论文。

受教育情况

1981-1985年 在北京大学生物系读本科，获得学士学位

1985-1987年 在中国农业科院生物技术研究中心获得硕士学位

1987-1989年 在中国农业科院生物技术研究中心获得博士学位

主要科研工作经历、主要学术任职：

1989-1992年 美国德克萨斯A&M大学生化和生物物理系 博士后研究助理

1992-1995年 美国Emory大学医学院医学系心脏科 博士后

1995-1998年 美国Emory大学医学院医学系心脏科 讲师

1998-2001年 美国Emory大学医学院医学系 助理教授

2001-2002年 美国堪萨斯大学医学中心医学系心血管科 副教授

2002-2005年 美国德克萨斯州大学生物化学和遗传学系，医学系、副教授

2005-2008年 美国Baylor医学院医学系 副教授

2008.2-至今 首都医科大学心血管病学系长江特聘教授，博士生导师，Baylor 医学院兼职副教授

社会任职：担任中华医学会心血管分会基础组副组长、中华生理学会循环生理专业委员会副主任委员、中国动脉粥样硬化委员会常委等。目前担任Cardiovascular Toxicology副主编，Arteriosclerosis, Thrombosis, and Vascular Biology 副主编，Cardiovascular Drugs and Therapy编委，Frontiers in Vascular Physiology编委，《中华分子心脏病学》副主编，《中国动脉硬化杂志》编委，《临床心血管病杂志》编委，《心肺血管疾病杂志》编委，《中华高血压杂志》编委， 《转化医学杂志》编委等。

发表的SCI文章

1. Jia LX, Qi GM, Liu O, Li TT, Yang M, Cui W, Zhang WM, Qi YF, Du J. Inhibition of Platelet Activation by Clopidogrel Prevents Hypertension-Induced Cardiac Inflammation and Fibrosis. Cardiovasc Drugs Ther. 2013; [Epub ahead of print]

2. Du J*, Jia L, Li Y, Ma X. Add Another Killer for Interfered Vascular Function Natural Killer Cells–Produced Interferon-γ Is a Cue. Arterioscler Thromb Vasc Biol. 2013; 33(6):1116-7.

3. Xue H, Xiao Z, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J*, Chen YG*. Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. J Biol Chem. 2013; 288(21):15006-14.

4. Zhang Y, Wang Y, Liu Y, Wang N, Qi Y, Du J*. Krüppel-Like Factor 4 Transcriptionally Regulates TGF-β1 and Contributes to Cardiac Myofibroblast Differentiation. PloS One. 2013; 8(4):e63424.

5. Zhang JM, Wang Y, Miao YJ, Zhang Y, Wu YN, Jia LX, Qi YF, Du J*. Knockout of CD8 Delays Reendothelialization and Accelerates Neointima Formation in Injured Arteries of Mouse via TNF-α Inhibiting the Endothelial Cells Migration. PloS One. 2013; 8(5):e62001.

6. Lin J, LiH, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J*, Han J*. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Report. 2013; 3(1):200-10.

7. Zeng Y, Wang HX, Guo SB, Yang H, Zeng XJ, Fang Q, Tang CS, Du J, Li HH. Transcriptional Effects of E3 Ligase Atrogin-1/MAFbx on Apoptosis, Hypertrophy and Inflammation in Neonatal Rat Cardiomyocyte. PLoS One. 2013; 8(1):e53831.

8. Qin YW, Teng X, He JQ, Du J, Tang CS, Qi YF. Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome. Peptides. 2013; doi: 10.1016/j.peptides.2013.01.011.

9. Teng X, Bian Y, Cai Y, Duan X, Yuan F, Du J, Wu W, Wang X, Tang C, Qi Y. Downregulation of Endogenous Intermedin Augmented Myocardial Injury in Rats Ischemic/Reperfusion. Horm Metab Res. 2013; 45(3):206-12.

10. Zhang C, Li Y, Wu Y, Wang L, Wang X, Du J*. Interleukin-6/STAT3 pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration. J Biol Chem. 2012; 288(3):1489-99.

11. Yang K, Zhang TP, Tian C, Jia LX, Du J, Li HH. Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein Inhibits Angiotensin II-Induced Cardiac Remodeling. Am J Hypertens. 2012; 25(9):994-1001.

12. Liu O, Jia L, Liu X, Wang Y, Wang X, Qin Y, Du J, Zhang H. Clopidogrel, a Platelet P2Y12 Receptor Inhibitor, Reduces Vascular Inflammation and Angiotensin II induced-Abdominal Aortic Aneurysm Progression. PLoS One. 2012; 7(12):e51707.

13. Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, Li H, Tang C, Du J, Shi GP. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res. 2012; 96(3):401-10.

14. Kikani CK, Verona EV,Ryu J,Shen Y, Ye Q, Zheng L, Qian Z, Sakaue H, Nakamura K, Du J, Ji Q, Ogawa w, Sun LZ, Dong LQ, Liu F. Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis. Sci. Signal. 2012; 5(249):ra80.

15. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J. Loss of Glutathione S-transferase A4 Accelerates Obstruction-induced Tubule Damage and Renal Fibrosis. J Pathol. 2012; 228:448-458.

16. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J*. Serum/glucocorticoid-regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II-induced Inflammation and Cardiac Fibrosis. Arterioscler Thromb Vascular Biol. 2012; 32(7):1675-86.

17. Li Y, Zhang C, Wu Y, Han Y, Jia L, Cai L, Li H, Du J*. Deficiency of interleukin-12 promotes CD4 T cell-dependent macrophage differentiation and enhances angiotensin II-induced cardiac fibrosis Arterioscler Thromb Vascular Biol. 2012; 32(7):1662-74.

18. Pan L, Li Y, Jia L, Qin Y, Qiu S, Qi G, Cheng J, Qi Y, Li H, Du J*. Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances angiotensin II–induced cardiac inflammation and fibrosis. PLoS One. 2012; 7(4):e35315.

19. Ma F, Li Y, Jia L, Han Y, Li H, Qi Y, Du J*. Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF-b/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One. 2012; 7(5):e35144.

20. Han Y, Li Y, Jia L, Cheng J, Qi Y, Du J*. Reciprocal Interaction between Macrophages and T cells Stimulates Interferon-g and MCP-1 Production in Angiotensin II-induced Cardiac Inflammation and Fibrosis. PLoS One. 2012; 7(5):e35506.

21. Zhang L, Dong Y, Dong Y, Cheng J, Du J. The Role of Integrin-β3 in Macrophage Polarization and Regeneration of Injured Muscle. J Biol Chem. 2012; 287(9):6177-86.

22. Zhou YB, Zhang J, Cai Y, Teng X, Duan XH, Song JQ, Du J, Tang CS, Qi YF. Insulin resistance induces medial artery calcification in fructose-fed rats. Exp Biol Med (Maywood). 2012; 237(1):50-7.

23. Jia L, Li Y, Xiao C, Du J*. Angiotensin II induces inflammation leading to cardiac remodeling. Front Biosci. 2012; 17:221-31.

24. Cheng J, Wang Y, Liang A, Jia L, Du J*. Silencing of FSP-1 in Bone Marrow Cells Suppresses Neointima Formation in Vein Graft. Circ Res. 2012; 110(2):230-40.

25. Zheng Y, Wang M, Tian C, Ma X, Chen H, Du J, Li H. Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. J Cell Physiol. 2012; 227(1):127-35.

26. Li W, Rong R, Zhao S, Zhu X, Zhang K, Xiong X, Yu X, Cui Q, Li S, Chen L, Cai J, Du J*. Proteomic analysis of metabolic, cytoskeletal, and stress response proteins in human heart failure. J Cell Mol Med. 2012; 16(1):59-71.

27. Zhao D, Qi Y, Zheng Z, Wang Y, Zhang XY, Li HJ, Liu HH, Zhang XT, Du J, Liu J. Dietary factors associated with hypertension. Nat Rev Cardiol. 2011; 8(8):456-65.

28. Teng X, Song J, Zhang G, Cai Y, Yuan F, Du J, Tang C, Qi Y. Inhibition of Endoplasmic Reticulum Stress by Intermededin(1-53) Protects Against Myocardioal Injury Through a PI3 kinase-Akt Signaling Pathway. J Mol Med 2011; 89(12):1195-205.

29. Chen G, Lin SC, Chen J, He L, Dong F, Xu J, Han S, Du J, Entman ML, Wang Y. CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol. 2011; 22(10):1876-86.

30. Wang Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S, Wang N. Krüppel-like Factor 4 is Induced by Rapamycin and Mediates the Anti-proliferative Effect of Rapamycin in Balloon-injured Rat Carotid Arteries. Br J Pharmacol. 2012; 165(7):2378-88.

31. Yang SW, Zhou YJ, Nie XM, Liu YY, Du J, Hu DY, Jia DA, Gao F, Hu B, Fang Z, Han HY, Liu XL, Yan ZX, Wang JL, Hua Q, Shi YJ, Li HW; BEAMIS Study Group. Effect of abnormal fasting plasma glucose level on all-cause mortality in older patients with acute myocardial infarction: results from the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS). Mayo Clin Proc. 2011; 86(2):94-104.

32. Yang H, Zeng XJ, Wang HX, Zhang LK, Dong XL, Guo S, Du J, Li HH, Tang CS. Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor. Peptides. 2011; 32(10):2108-15.

33. Zhang Y, Kang YM, Tian C, Zeng Y, Jia LX, Ma X, Du J, Li HH. Overexpression of nrdp1 in the heart exacerbates Doxorubicin-induced cardiac dysfunction in mice. PLoS One. 2011; 6(6):e21104.

34. Li JJ, Zhang TP, Meng Y, Du J, Li HH. Stability of F-box Protein Atrogin-1 is Regulated by p38 Mitogen-activated Protein Kinase Pathway in Cardiac H9c2 Cells. Cell Physiol Biochem. 2011; 27(5):463-70.

35. Qi G, Jia L, Li Y, Bian Y, Cheng J, Li H, Xiao C, Du J* Angiotensin II Infusion-Induced Inflammation, Monocytic Fibroblast Precursor Infiltration and Cardiac Fibrosis is Pressure-Dependent. Cardiovasc Toxicol. 2011; 11(2):157-67.

36. Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J* . Proinflammatory Protein CARD9 is Essential for Infiltration of Monocytic Fibroblast Precursors and Cardiac Fibrosis Caused by Angiotensin II Infusion. Am J Hypertens. 2011; 24(6):701-7.

37. Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J*, Li H*. Cardiac-specific overxpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury Basic Res Cardiol. 2011; 106(3):371-83.

38. Li H, Du J, Fan Y, Zhang M, Liu D, Li L, Lockyer P, Kang E, Patterson C, Willis MS. The ubiquitin ligase Muscle Ring Finger-1 (MuRF1) protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. Am J Pathology. 2011; 178(3):1043-58.

39. Zhang L, Rajan V, Liu E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch W. Pharmacological Inhibition of Myostatin Suppresses Systemic Inflammation and Muscle Atrophy in Mice with Chronic Kidney Disease. FASEB J. 2011; 25(5):1653-63.

40. Cheng J, Wang Y, Ma Y, Yang M, Chan T, Zhang L, Li H , and Du J*. The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes neointima formation in vein grafts. Circ Res. 2010; 107(10):1265-74.

41. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J* . Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010; 78(7):668-78.

42. Liu S, Shen H, Xu M, Liu O, Zhao L, Liu S, Guo Z, Du J. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. Am J Physiol Endocrinol Metab. 2010; 299(3):E351-63.

43. Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML. Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010;49(3):499-507.

44. Wu X, Cheng J, LiP Yang M, Qiu S, Liu P, Du J*.Mechano-Sensitive Transcriptional Factor Egr-1 Regulates Insulin-Like Growth Factor-1 Receptor Expression and Contributes to Neointima Formation in Vein Grafts. Arterioscler Thromb Vasc Biol. 2010; 30(3):471-6.

45. HuZ, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high fat diet. Diabetes. 2010; 59(6):1312-20.

46. Wang XH, Zhang L, Mitch WE, LeDoux JM, Hu J, Du J*. Caspase-3 cleaves specific 19S proteasome regulatory subunits in skeletal muscle stimulating proteasome activity. J Biol Chem. 2010; 285(28):21249-57.

47. Hu J, Du J, Zhang LP, Pricce RS. Klein J Wang XH. Muscle Specific Expression of XIAP Blocks Proteolysis by Inhibition of Murf-1 in Chronicle Kidney Diseases Mice. J Am Soc Nephrol. 2010; 21(7):1174-83.

48. Zhang LP, Wang XH, Wang H, Du J, Mitch WE. Satellite Cell Dysfunction and Impaired IGF-1 Signaling cause CKD-Induced Muscle Atrophy. J Am Soc Nephrol. 2010; 21(3):419-27.

49. Qin YW, Ye P, He JQ, Sheng L, Wang LY, DU J. Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. Acta Pharmacol Sin. 2010; 31(10):1350-8.

50. Liu O, Li JR, Gong M, Xu M, Du J*, Zhang HJ. Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population. Acta Pharmacol Sin. 2010; 31(10):1376-80.

51. Wang XH, Du J, Klein J, Baiely J and Mitch WE. Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. Kidney Int. 2009; 76(7):751-9.

52. Zhang LP, Ran LM, Garcia GE, Wang XN, Han SH, Du J*, Mitch WE. Chemokine CXCL16 Regulates Neutrophil and Macrophage Infiltration into Injured Muscle Promoting Muscle Regeneration. Am J Pathol. 2009; 175(6):2518-27.

53. Hu Z, Wang H, Lee IN, Du J*, Mitch WE*. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009; 119(10):3059-69.

54. Zhang LP, Du J*, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol. 2009; 20(3):604-12.

55. Luo Y, Tian W, Cai L, Wang Y, Zhang J, Teng H, Du J, Sun ZS. Expression profiling reveals a positive regulation by mPer2 on circadian rhythm of cytotoxicity receptors: Ly49C and Nkg2d. Chronobiol Int. 2009; 26(8):1515-44.

56. Wang X, Hu Z, Du J, Klein J. Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology. 2008; 149(11):5384-90.

57. Garcia GE, Troung LD, Li P, Zhang P, Du J, Chen JF, Feng L. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J. 2008; 22(2):445-54.

58. Zhu Q, Youn H, Tang J, Tawfik O, Dennis K, Terranova PF, Du J, Raynal P, Thrasher JB, Li B. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene. 2008; 27(33):4569-79.

59. Cheng JZ, Du J*. Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arterioscler Thromb Vasc Biol. 2007; 27(8):1744-51.

60. Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Troung L Boriek AM, Du J*. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. J Biol Chem. 2007; 282(47):34268-75.

61. Cheng JZ, Cui RW, Chen C, Du J*. Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology. 2007; 148 (5): 2085-94.

62. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J and Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007; 56(10):2449-56.

63. Zhou Q, Du J, Hu Z, Walsh K, Wang XH. Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Endocrinology. 2007; 148(12):5696-705.

64. Cheng JZ, Du J*. Mechanical Stretch Simulates Proliferation of Venous Smooth Muscle Cells through Activation of the Insulin-like Growth Factor-1 Receptor. Arterioscler Thromb Vasc Biol. 2007; 27(8):1744-51.

65. Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Troung L Boriek AM, Du J*. Mechanical stretch suppresses Ox-LDL-induced apoptosis in vascular smooth muscle cells by upregulating integrin alphavbeta 3 and stabilization of PINCH-1. J Biol Chem. 2007; 282(47):34268-75.

66. Cheng JZ, Cui RW, Chen C, Du J*. Oxidized Low-density Lipoprotein Stimulates p53-dependent Activation of Pro-apoptotic Bax Leading to Apoptosis of Differentiated Endothelial Progenitor Cells. Endocrinology. 2007; 148 (5): 2085-94.

67. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007; 56(10):2449-56.

68. Zhou Q, Du J, Hu Z, Walsh K, Wang XH. Evidence for Adipose-Muscle Crosstalk: Opposing Regulation of Muscle Proteolysis by Adiponectin and Fatty Acids. Endocrinology. 2007; 148(12):5696-705.

69. Wang X, Hu J, Du J, Klein J. X-cheromosome Linked inhibitor of apoptosis protein (XIAP) inhibits muscle proteolysis in insulin deficient mice. Gene Therapy. 2007; 14 (9): 711-20.

70. Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J*. Angiotensin II Stimulates Transcription of Insulin-like Growth Factor 1 Receptor in Vascular Smooth Muscle Cells: Role of NF-kB. Endocrinology. 2006; 147(3):1256-63.

71. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a Diagnostic Method for Detecting Increased Muscle Protein Degradation in Patients with Catabolic Conditions. J Am Soc Nephrol. 2006; 17(11):3233-9.

72. Wang X, Hu J, Hu Z, Du J, Mitch WE. Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling. Endocrinology. 2006; 147(9):4160-8.

73. Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J*. Dual Pathways for Nuclear Factor kB Activation by Angiotensin II in Vascular Smooth Muscle: Phosphorylation of p65 by kB Kinase and Ribosomal Kinase. Circ Res. 2005; 97(10):975-82.

74. Zhang L, Ma Y, Zhang J, Cheng J, Du J*. A New Cellular Signaling for Angiotensin II Activation of NF-kB: an IkB-independent, RSK-mediated Phosphorylation of p65. Arterioscler Thromb Vasc Biol. 2005; 25(6):1148-53.

75. Zhang L, Cui R, Cheng X, Du J*. Anti-apoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase is Mediated by Activating Nuclear Transcription Factor kB. Cancer Res. 2005; 65(2): 457-64.

76. Song Y, Li Y, Du J, Mitch W., Rosenthal N and Delafontaine P. Muscle-Specific Expression of Insulin-like Growth Factor-1 Blocks Angiotensin II-induced Skeletal Muscle Wasting. J Clin Invest. 2005; 115(2): 451-8.

77. Higashi Y, Peng T, Du J, Sukhanov S, Li Y, Itabe H, Parthasarathy S, Delafontaine P. A Redox-sensitive Pathway Mediates Oxidized LDL-induced Downregulation of Insulin-like Growth Factor-1 Receptor. J Lipid Res. 2005; 46(6):1266-77.

78. Du J, Mitch WE. Identification of Pathways Controlling Muscle Protein Metabolism in Uremia and Other Catabolic Conditions. Curr Opin Nephrol Hypertens. 2005; 14(4):378-82.

79. Du J, Hu Z, Mitch WE. Molecular Mechanisms Activating Muscle Protein Degradation in Chronic Kidney Disease and Other Catabolic Conditions. Eur J of Clin Invest. 2005; 35(3):157-63.

80. Du J, Hu Z, Mitch WE. Cellular Signals Activating Muscle Proteolysis Chronic Kidney Disease: A Two Stage Process. Int Biochem Cell Biol. 2005; 37(10):2147-55.

81. Mitch W, Hu Z, Lee S, Du J. Strategies for Suppressing Muscle Atrophy in Chronic Kidney Disease: Mechanisms Activating Distinct Proteolytic Systems. J Renal Nutrition. 2005; 15(1): 23-7.

82. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE. Regulation of Muscle Protein Degradation: Coordinated Control of Apoptotic and Ubiquitin-proteasome Systems by Phosphatidylinositol 3 Kinase. J Am Soc Nephrol. 2004; 15 (6): 1537-45.

83. Mitch WE, Du J. Cellular Mechanisms Causing Loss of Muscle Mass in Kidney Disease. Semin Nephrol. 2004; 24(5): 484-7.

84. Du J, Wang X, Miereles C, Bailey J, Zheng B, Price S, Mitch W. Activation of Caspase-3 is an Initial Atep Triggering Accelerated Muscle Proteolysis in Catabolic Conditions. J Clin Invest. 2004; 13(1):115-23.

85. Li Y, HigashiY, Itabe H, Song YH, Du J, Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway. Arterioscler Thromb Vasc Biol. 2003; 23(12):2178-84.

86. Liao X, Thrasher J, Du J, Li B. GSK-3b Suppression Overcomes TRAIL Resistance in Prostate Cancer. Molecular Cancer Therapy 2003; 3:1215-21.

87. Zhang J, Fu M, Myles D, Zhu X, Du J, Cao X, Chen Y. PDGF Induces Osteoprotegerin Expression in Vascular Smooth Muscle Cells by Multiple Signal Pathways. FASEB J. 2002; 521(1-3):180-4.

88. Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H. Shear Stress Stimulates Phosphorylation of eNOS at Ser1179 by Akt-independent Mechanisms - Role of Protein Kinase A. J Biol Chem. 2002; 277(5): 3388-96.

89. Franch H, Sooparb S, Du J .Phosphatidylinositol 3-Kinase Activity is Required for Epidermal Growth Factor to Suppress Proteolysis. J Am Soc Nephrol. 2002; 13(4):903-9.

90. Fu M, Zhu X, Xheng H, Du J, Chen E. Platelet-Derived Growth Factor Promotes the Expression of Peroxisome Proliferator-Activated Receptor g in Vascular Smooth Muscle Cells by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. Circ Res. 2001; 89(11):1058-1064.

91. Du J, Brink M, Peng T, Delafontaine P. Thrombin Regulates Insulin-like Growth Factor-1 Receptor Transcription in Vascular Smooth Muscle: Characterization of the Signaling Pathway. Circ Res. 2001; 88(10):1044-52.

92. Franch HA, Sooparb S, Du J, Brown NS. A Mechanism Regulating Proteolysis of Specific Proteins during Renal Tubular Cell Growth. J Biol Chem. 2001; 276(22):19126-31.

93. Price S, Du J, Bailey J, Mitch W. Molecular Mechanisms Regulating Protein Turnover in Muscle. Ame J of Kid Diseases. 2001; 37(1):112-4.

94. Du J, Mitch WE, Wang X, Price SR. Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kappa B. J Biol Chem. 2000; 275(26):19661-6.

95. Du J, Peng T, Scheidegger KJ, Delafontaine, P. Angiotensin II Activation of Insulin-like Growth Factor 1 Receptor Transcription is mediated by a Tyrosine Kinase-Dependent Redox-sensitive Mechanism. Arterioscler Thromb Vasc Biol. 1999; 19(9):2119-26.

96. Scheidegger K, Du J, Delafontaine P. Distinct and Common Pathways in the Regulation of Insulin-like Growth Factor-1 Receptor Gene Expression by Angiotensin II and Basic Fibroblast Growth Factor. J Biol Chem.1999; 274(6):3522-30.

97. Mitch WE, Du J, Bailey JL, Price SR. Mechanisms Causing Muscle Proteolysis in Uremia: The Influence of Insulin and Cytokines. Miner Electrolyte Metab. 1999; 25(4-6):216-19.

98. Delafontaine P, Brink M, Du J. Angiotensin II Modulation of Insulin-like Growth Factor 1 Expression in the Cardiovascular System. Trends Cardiova Med. 1996; 6(6):187-93.

99. Du J, Meng XP, Delafontaine P. Transcriptional Regulation of the Insulin-like Growth Factor-1 Receptor Gene: Evidence for Protein Kinase C-dependent and Independent Pathways. Endocrinology 1996; 137(4):1378-84.

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